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Partnering with Clinicians to Transform Mental Health Through Metabolic Care


What is Metabolic Psychiatry?

​Metabolic Psychiatry is an emerging and powerful paradigm shift that bridges the gap between physical and mental health care. By addressing underlying metabolic dysfunction - such as insulin resistance, mitochondrial impairment, oxidative stress, and inflammation - we can help improve outcomes for patients living with depression, anxiety, bipolar disorder, OCD, ADHD, schizophrenia, and more.

We partner with clinicians and patients to support the integration of metabolic principles into mental health care - empowering both with tools, education, and patient engagement strategies to enhance healing from the inside out.

Why Metabolic Psychiatry Matters
  • Root-Cause Insight: Metabolic Psychiatry explores the biological drivers of mental illness, especially metabolic dysfunction and mitochondrial impairment - offering hope for treatment-resistant conditions.
  • High Comorbidity Rates: Up to 80% of individuals with serious mental illness also suffer from metabolic disorders such as obesity, diabetes, or cardiovascular disease. This overlap calls for a unified approach to care. 
  • Mitochondria and Mental Health: As Dr. Chris Palmer outlines in Brain Energy (2022), mitochondrial dysfunction may be the unifying mechanism linking metabolic and mental illnesses. Stabilizing energy production through lifestyle and dietary interventions has led to remarkable outcomes in both clinical trials and real-world cases.
  • Balancing Life-Saving Treatments with Long-Term Health: While many medications - particularly antipsychotics, mood stabilizers, and certain antidepressants - are essential, often life-saving treatments, they are also associated with metabolic side effects i.e. insulin resistance, weight gain, dyslipidemia, and increased risk for cardiovascular disease and type 2 diabetes.
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Clinical Approaches in Metabolic Psychiatry

Metabolic psychiatry is not “alternative”- it’s evidence-based, integrative care. Common interventions include:
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  • Ketogenic and Low-Carbohydrate Diets: Ketogenic diets have shown promise in improving mood, cognition, and functioning- particularly in bipolar disorder, schizophrenia, and OCD.
  • Exercise & Circadian Optimization: Physical activity improves insulin sensitivity, enhances brain-derived neurotrophic factor (BDNF), and supports neuroplasticity. Sleep quality and circadian rhythm regulation are also essential in managing mood disorders.
  • Metabolic Medications: GLP-1 receptor agonists, metformin, and others are being investigated for their potential to improve both metabolic and psychiatric outcomes, especially in treatment-resistant depression and schizophrenia.
  • Nutritional Psychiatry: Whole-food, anti-inflammatory nutrition that stabilizes blood sugar and supports gut-brain axis health is foundational in this model. Dietary strategies that lower insulin and reduce inflammation also improve symptoms in ADHD, depression, and anxiety.

​Collaborate with Us

We work alongside psychiatrists, psychologists, primary care providers, and integrative teams to offer:
  • Patient Engagement & Coaching: Supporting behavior change, dietary interventions, and lifestyle integration for improved adherence and outcomes.
  • Care Coordination: Aligning nutrition, movement, sleep, and stress regulation with clinical treatment plans.
  • Clinician Education: Access to science-backed resources and emerging protocols in metabolic psychiatry.

Whether you’re treating mood disorders, cognitive decline, or complex chronic illness, our collaborative model helps you offer personalized, root-cause solutions that empower your patients and expand your toolkit.

© WellSelf 360. Educational content only - not medical advice or a substitute for care. Not a healthcare provider.
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  • Home
  • Metabolic Health
    • Why It Matters
    • Our Approach
    • Coaching + Courses
    • Metabolic Reset Program
    • Metabolic Psychiatry
  • Services
    • Individuals + Families
    • Healthcare Providers
    • Advocacy, Research + Policy Advancement
    • Corporate Wellness
    • Speaking + Workshops
  • About
  • Resources
  • Let's Connect